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OBJECTIVE： To evaluate risk factors of linezolid-induced thrombocytopenia systematically， and to provide reference for rational drug use in clinic. METHODS： Retrieved from PubMed， Embase， Cochrane library， Web of Science， CBM， CNKI and Wanfang database， during database establishment to Oct. 2018， clinical studies about risk factors of linezolid-induced thrombocytopenia were collected， and the data of literatures met criteria were collected. After Newcastle-Ottawa scale （NOS） was applied for evaluating the quality of included literatures. Meta-analysis was conducted by using Rev Man 5.3 software. RESULTS： Sixteen clinical studies involving 2 264 patients in total were included. Results of Meta-analysis showed that daily per kg dose （DKPD） [SMD＝0.62， 95％CI（0.29，0.95）， P＝0.000 2]， low platelet count before medication [SMD＝－0.90， 95％CI（－1.62， －0.18）， P＝0.01]， low creatinine clearance rate [SMD＝－0.65， 95％CI（－1.10，－0.19）， P＝0.005]， long treatment course [SMD＝0.45， 95％CI（0.18，0.71）， P＝0.000 9]， low body weight [SMD＝－0.36， 95％CI（－0.60，－0.11），P＝0.005] significantly influenced the occurrence of thrombocytopenia. CONCLUSIONS： The risk factors associated with linezolid-induced thrombocytopenia include low baseline platelet count， low creatinine clearance rate， low body weight， long medication course and high DKPD.
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Objective To explore the clinical expression of P53, Livin and PARP in the epithelial ovarian cancer and its correlation with the chemotherapy resistance and clinical prognosis.Methods 74 specimen of epithelial ovarian cancer confirmed from January 2009 to June 2011 in our gynecology department were selected.During the follow-up visit, the subjects were divided into chemotherapy sensitivity group and chemotherapy resistance group according to the recurrence cases, the clinical expression and survival rate for two groups were compared, the influence factors of survival time were analyzed.Results The positive rate of P53, Livin and PARP for chemotherapy sensitivity group was 47.1%, 56.9%and 52.9%;the positive rate for chemotherapy resistance group was 73.9%, 95.7% and 95.7%,the diyforences were significant(P<0.05).After 1, 3 and 5 years of treatment, the survival rate for chemotherapy sensitivity group was 100.0%, 82.4% and 66.7%,The survival rate for chemotherapy resistance group was 87.0%, 26.1% and 8.7%,the diyforences were significant(P<0.05).Based on the Cox regression model, the influence factors of the patient's age, pathological differentiation degree, clinical staging and chemotherapy sensitivity were introduced.It was known that the patient's survival time was greatly influenced by clinical staging and chemotherapy sensitivity (P<0.05).Conclusion For patients with epithelial ovarian cancer, the expression of P53, Livin and PARP is correlated with chemotherapy resistance.Therefore, the clinical effect is predictable, for patients with higher expression, the personalized therapy can improve the patient's prognosis.
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OBJECTIVE:To systematically review the efficacy and safety of insulin glargine versus premixed insulin in treat-ment of type 2 diabetes,and provide evidence-based reference for clinical treatment. METHODS:Retrieved from PubMed,CJFD, Wanfang Database and VIP Database,the randomized controlled trials(RCT)about the efficacy and safety of premixed insulin ver-sus insulin glargine in the treatment of type 2 diabetes were collected. Meta-analysis was performed by using Rev Man 5.0 statistics software after extracting data and evaluating quality by modified Jadad. RESULTS:A total of 10 RCTs were enrolled,involving 1 655 patients. Results of Meta-analysis showed that insulin glargine was better than premixed insulin on reducing glycated hemoglobin [M=-0.41,95% CI(-0.64,-0.18),P<0.001] and fasting blood glucose [MD=-0.51,95% CI(-0.99,-0.02),P=0.04], there were significantly differences between 2 groups,and there were no significantly differences in reducing 2 h postprandial blood glucose [MD=-0.56,95% CI(-1.21,0.09),P=0.09] and body mass index [MD=-0.52,95% CI(-1.52,0.48),P=0.31];the incidence of hypoglycemia in insulin glargine group was significantly lower than premixed insulin,there were significantly differ-ences between 2 groups [RR=0.65,95%CI(0.46,0.90),P=0.01]. CONCLUSIONS:The efficacy and safety of insulin glargine are better than premixed insulin in the treatment of type 2 diabetes.
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Objective To investigate the effect against exercise-indused fatigue in mice by aqueous extract of Ludisia dis-color and its mechanism .Methods Male mice were randomly divided into five groups including low ,middle ,high dose groups [aqueous extract of Ludisia discolor at dose of 1 .22 ,2 .44 ,4 .88 g/(kg · d) respectively ] ,positive control group [aqueous ex-tract of Rhodiola ,at dose of 2 .34 g/(kg · d)] and control group (distilled water ) .After intragastric administration for seven days ,mice were measured for loading swimming time ,and were tested 90 minutes after loading swimming for blood urea nitro-gen ,blood lactic acid and hepatic glycogen levels .Results The blood urea nitrogen was significantly decreased (P<0 .05) in aqueous extract of Ludisia discolor groups ,and hepatic glycogen was significantly increased (P<0 .05) in a dose-dependent manner .The blood lactic acid was significantly decreased in high dose group ,and weight loading swimming time was prolonged (P<0 .05) .The effects of Ludisia discolor is similar compared to Rhodiola .Conclusion The aqueous extract of Ludisia dis-color has anti-fatigue action in mice .The mechanism might be related with the increased glycogen reserves ,increased glucose aerobic decomposition ,as well as reduced anaerobic glucolysis and reduced protein breakdown .
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OBJECTIVE:To screen Gongshisong's active sites for anti-sports fatigue. METHODS:Gongshisong extract was prepared with 80% ethanol extraction technology,and extracted with petroleum ether,chloroform,ethyl acetate and n-butyl alco-hol after dispersed with water to obtain the extract. 70 mice were randomly divided into blank control group(1% sodium carboxy-methylcellulose,CMC-Na),positive control group [Rhodiola wallichiana capsules,590 mg/(kg·d)],petroleum ether,chloro-form,ethyl acetate and n-butyl alcohol extracts and aqueous layer of Gongshisong groups(TS,TL,TY,TZ,TW groups). Gong-shisong extracts groups was given relevant medicine 2.5 g(crude drug)/(kg·d),ig,for consecutive 7 days. Exhaustion time of bur-den swimming test was detected. 70 mice were grouped according to above method,and the contents of liver glycogen,muscle gly-cogen and the coefficient of liver were tested in mice. 80 mice were grouped according to above method,and model group was es-tablished additionally(1% CMC-Na). The contents of lactic acid(LA),creatine kinase(CK)and urea nitrogen(BUN)in serum of mice were determined after 90 minutes of unburden swimming. RESULTS:Compared with blank control group,exhaustion time of burden swimming mice in TS,TY and TZ groups prolonged;the content of liver glycogen increased in TY,TZ and TW groups;the content of muscle glycogen increased in TS and TW groups;the contents of BUN,LA and CK in mice increased in model group (P<0.05 or P<0.01). Compared with model group,the serum content of BUN in mice decreased in TS and TY groups;that of LA in mice decreased in TZ and TW groups;that of CK in mice decreased in TS group (P<0.05 or P<0.01). CONCLUSIONS:The petroleum ether and n-butanol extract site and water layer of Gongshisong are good anti-fatigue active sites.
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OBJECTIVE:To provide reference for clinical rational drug use. METHODS:The drug sales amount,DDDs, DDC and major pharmaceutical enterprises in 273 sample hospitals of Yangtze River basin in 2014 were statistically analyzed. RE-SULTS:The growth of consumption sum slowed down gradually. The anti-infective drugs,cardiovascular drugs and nervous sys-tem drugs occupied the medical mainstream market. Top 3 drugs in the list of consumption sum in consecutive 4 quarters were monosialotetrahexosylganglioside,thymic peptide and lansoprazole. Nearly half of top 15 drugs were auxiliary drugs;Chinese pat-ent medicines grew increasingly and appeared in the list. The sales enterprises were mainly domestic enterprises,which concentrat-ed in Sichuan,Chongqing,Jiangsu province,and other places. CONCLUSIONS:The structure of drug use in sample hospitals is basically consistent with the spectrum of disease in China. However,there is deviation between auxiliary drug use and international guide,and the rationality of clinical drug use needs to be improved.
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Objective To study the clinical value of analyzing lipids indexes in patient with coronary heart disease(CHD).Methods seventy nine patients were chosen to CHD group;health group contain 70 people.Levels of lipids indexes were measured,the ROC curve was used to comparison and analysis.Results There were significantly difference in Lp(a)、TC、TG、HDL-C、ApoA1 and A1/B(P0.7 and had significant difference(P